Serum cholesterol levels and the risk of multiple system atrophy: A case‐control study
Identifieur interne : 000960 ( Main/Exploration ); précédent : 000959; suivant : 000961Serum cholesterol levels and the risk of multiple system atrophy: A case‐control study
Auteurs : Phil Hyu Lee [Corée du Sud] ; Tae Sung Lim [Corée du Sud] ; Hae-Won Shin [Corée du Sud] ; Seok Woo Yong [Corée du Sud] ; Hyo Suk Nam [Corée du Sud] ; Young H. Sohn [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
English descriptors
Abstract
Cholesterol in brain membranes may modulate the conformational state and accumulation of α‐synuclein in α‐synucleinopathies.We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α‐synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age‐ and gender‐matched healthy people with no neurological disease. The levels of total cholesterol, low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL‐C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL‐C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol‐lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3–11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2–5.5, P = 0.016) for those in the lowest quartile of HDL‐C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22459
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-15">2009-04-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="752">752</biblScope><biblScope unit="page" to="758">758</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8B4302F9CD6DEAA346E99C7B6C798A8B481EECBE</idno><idno type="DOI">10.1002/mds.22459</idno><idno type="ArticleID">MDS22459</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HDL‐cholesterol</term><term>multiple system atrophy</term><term>total cholesterol</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cholesterol in brain membranes may modulate the conformational state and accumulation of α‐synuclein in α‐synucleinopathies.We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α‐synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age‐ and gender‐matched healthy people with no neurological disease. The levels of total cholesterol, low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL‐C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL‐C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol‐lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3–11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2–5.5, P = 0.016) for those in the lowest quartile of HDL‐C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name></noRegion><name sortKey="Lim, Tae Sung" sort="Lim, Tae Sung" uniqKey="Lim T" first="Tae Sung" last="Lim">Tae Sung Lim</name><name sortKey="Nam, Hyo Suk" sort="Nam, Hyo Suk" uniqKey="Nam H" first="Hyo Suk" last="Nam">Hyo Suk Nam</name><name sortKey="Shin, Hae On" sort="Shin, Hae On" uniqKey="Shin H" first="Hae-Won" last="Shin">Hae-Won Shin</name><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name><name sortKey="Yong, Seok Woo" sort="Yong, Seok Woo" uniqKey="Yong S" first="Seok Woo" last="Yong">Seok Woo Yong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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